• Newly-developed HK Biotechnologies Leads Healthy Life over 100 Years Old.

New Products and Technology 목록

New Products and Technology


Health functional food ingredient for blood pressure control of shiitake mushroom mycelium culture containing ERITADENINE (EA)

Chemical structure of Eritadenine [2(R),3(R)-dihydroxy-4-(9-adenyl)butanoic acid; EA]

Hyperlipidemia and blood cholesterol lowering effect of EA
In numerous studies on EA derived from shiitake mushrooms, EA has focused on the anti-hyperlipidemic and anti-hypercholesterolemic effects by lowering total cholesterol, lowering LDL, increasing HDL and lowering TG in laboratory animals and humans.
Blood pressure control effect of EA and EA-containing shiitake mushroom mycelium
EA inhibited the activity of angiotensin converting enzyme (ACE) which was similar to that of an antihypertensive drug captopril.
EA lowered blood pressure in hypertension rats (HR).
Shiitake mushroom mycelium containing EA lowered blood pressure in rats induced with L-NAME.
Advantage of EA-containing shiitake mushroom mycelium for blood pressure control health functional food ingredients
Blood pressure lowering effect of EA + blood cholesterol lowering effect (synergistic effect)
Synergistic effect of shiitake mushroom mycelium culture on reduction of blood pressure with liver health
Additive effect on physiological activity of various substances contained in shiitake mushroom mycelium culture
ACE inhibitory effect of EA
EA was a competitive inhibitor of ACE and had an IC50 of 0.091 μM (91 nM) compared to the reference drug Captopril (0.025 μM (25 nM). Afrin S., et al., J. Agric. Food Chem. 2016., doi:10.1021/acs.jafc.5b05869.

Research papers and patents

Research papers
Sadia Afrin et al. Eritadenine from Edible. Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 64, 2263-8 (016). doi: 10.1021/acs.jafc.5b05869.
Composition for anti-oxidant and anti-inflammatory comprising eritadenine as effective component. KR10-2104425 (2020. 04. 20).
Composition for stimulating Testosterone comprising eritadenine as effective component. KR10-2020336 (2019. 09.).
Composition for preventing, treating and improving hypertension comprising eritadenine as effective component and extraction method of eritadenine. (KR10-2016-0085529).